en aquaculture aquaculture پژوهشي Orginal research papers <p><span style="font-size:11pt"><span calibri="" style="font-family:"><span style="color:black">The effect of fishmeal (FM) replacement with Spirulina (<em>Arthrospira platensis</em>) meal (SPM) was investigated in Asian seabass (<em>Lates calcarifer</em>) diet. Dietary FM was replaced with SPM at 5 (SP5%) and 10% (SP10%) and a diet without SPM served as the control group. One hundred and thirty five <em>L. calcarifer</em> juveniles (45.0 &plusmn; 0.2 g) were randomly distributed into nine 300-L circular polyethylene tanks (15 fish/tank). SP10% group had the highest final weight that was associated with better feed conversion ratio value. A higher gut amylase activity was observed in SPM-treated groups than the control group. SP5% group had a higher gut trypsin activity than other treatments. The liver superoxide dismutase activity in SP5% was higher than the other groups. The liver reduced glutathione level increased with increasing SPM level in the diets. The plasma lysozyme activity in SP10% group was higher than other groups. The plasma cholesterol and alkaline phosphatase contents decreased in the fish fed with SP5%. The plasma aspartate aminotransferase decreased in the fish fed with SPM-supplemented diets. Based on the above-mentioned findings, dietary FM replacement with SPM at 10% is recommended for growth and improving health status in <em>L. calcarifer</em> juveniles.</span></span></span></p> Asian seabass, Antioxidant capacity, Digestive enzymes, Hypocholesterolemic effect, Lysozyme, Microalgae 405 421 http://jifro.ir/browse.php?a_code=A-10-2213-3&slc_lang=en&sid=1 P. Mousavi parva.mousavi@gmail.com 100319475328460055338 100319475328460055338 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran T. Mohammadian takavar.mohammadian@gmail.com 100319475328460055339 100319475328460055339 Yes Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran M. Torfi Mozanzadeh mansour.torfi@gmail.com 100319475328460055340 100319475328460055340 No South Iran Aquaculture Research Centre, Iranian Fisheries Science Institute (IFSRI), Agricultural Research Education and Extension organization (AREEO), Ahwaz, Iran, https://orcid. org/0000‐0002‐2011‐799X H. Alamifar hamed.alamifar@gmail.com 100319475328460055341 100319475328460055341 No Aquatic Animal Health & Diseases Department, School of Veterinary Medicine, Shiraz University, Shiraz, Iran M. Mesbah mehrzad.mesbah@gmail.com 100319475328460055342 100319475328460055342 No Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran M. Khosravi mohammad.khosravi@gmail.com 100319475328460055343 100319475328460055343 No Member of Excellence Center of Warm Water Fish Health, Shahid Chamran University of Ahvaz, Ahvaz, Iran